Temporary joint discomfort and stiffness can occur at any age, typically from overuse or injury. But it's everyday wear-and-tear, extreme physical activity, or competitive sports that may lead to chronic discomfort. Glucosamine, chondroitin, and MSM can help maintain healthy joint function. Collagen is a major structural protein in healthy joints , and helps support and maintain healthy joint function. Doctor’ s Best's joint supplements may enhance your comfort, mobility, and flexibility as you pursue an active lifestyle.